|Episode First Shown in||It's Mr. Mime Time|
|First Known Owner||Stella|
|First Game Appeared in|
|National Dex Number||122|
Mr. Mime has a round, white body with a red spot in the middle. Its pink arms and legs are connected to its body by red spheres. Mr. Mime has white, five-fingered hands and black feet that curl up at the end. Mr. Mime has a pink head with red cheeks and a pair of blue horns.
- A Mr. Mime appeared in The Show Must Go On!
- A Mr. Mime was part of Lawrence's Collection in The Collector. It was freed in the end.
- Sabrina's Mr. Mime debuted in Vs. Natu.
- Noland's Mr. Mime appeared in Vs. Battle Factory.
- A trainer's Mr. Mime appeared in Morning of Disaster.
- Clayton's Mr. Mime appeared in Vs. Pupitar and Vs. Claydol.
- Multiple Mr. Mimes appeared as guards of the factory in The Porygon Factory. One set up a Light Screen to block Spencer.
- Magical Leaf
- Quick Guard
- Wide Guard
- Power Swap
- Guard Swap
- Light Screen
- Role Play
- Baton Pass