|Episode First Shown in||A Bite to Remember|
|First Known Owner||Butch|
|First Game Appeared in|
|National Dex Number||262|
Mightyena has black legs, a black tail, and a black mane. The rest of its body is gray. It has pointed ears, with black insides, a small red nose, and a triangular marking under its eye.
- The Pokémon Trainer School's Mightyena appeared in Vs. Slugma.
- Tabitha's Mightyena appeared in Vs. Mightyena.
- Team Magma Grunts used Mightyena in Vs. Natu.
- A coordinator's Mightyena appeared in Vs. Wigglytuff.
- Shadow the Mightyena, owned by Dakota Rex, appeared in Daddy Issues: Raising the Prince of the Sea.
- Wild Mightyena appeared in Daddy Issues: Raising the Prince of the Sea.
- Sidney's Mightyena appeared in Vs. Sidney. Its ability is Intimidate.
- Ben's Mightyena, nicknamed Blitzwolfer, debuted in Gem of the Future.
- A trainer's Mightyena appeared in the Pokémon Dress Up Contest in Vs. Chatot.
- Katrina's Mightyena appeared in Vs. Seviper and Zangoose.
- Odor Sleuth
- Scary Face
- Take Down
- Sucker Punch